Vaccine Research and Development Center
DEJIMA Infectious Disease Research Alliance
Nagasaki University

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12924226 1 apa 50 default desc year 1 1 567 https://dida.nagasaki-u.ac.jp/dida_wp/wp-content/plugins/zotpress/
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Raekiansyah, M., Rahmasari, R., Baihaqy, F., Irhamsyah, M., Fajriani, N. I., Putri, M. M., Maharani, B., Sauriasari, R., Urano, T., Ngwe Tun, M. M., & Morita, K. (2025). High Concordance Between SYBR Green and TaqMan PCR for SARS-CoV-2 Detection in Nasopharyngeal and Saliva Samples. Viruses, 17(8), 1130. https://doi.org/10.3390/v17081130 Cite
Raekiansyah, M., Ngwe Tun, M. M., Ang, A., Lee, A., Macalino, S. J., Billones, J., Takamatsu, Y., Urano, T., Murao, L. A. E., Quiming, N., Morita, K., & Carrillo, M. C. (2025). Antiviral Activity of Medicinal Plant Extracts Vitex negundo and Macaranga tanarius Against SARS-CoV-2. Pathogens, 14(8), 820. https://doi.org/10.3390/pathogens14080820 Cite
Ngwe Tun, M. M., Nwe, K. M., John, J. L., Mumo, M., Manah, A. M., Takamatsu, Y., Urano, T., Morita, K., & Ahmed, K. (2025). Molecular and Serological Detection of Zika Virus and Zika–Dengue Virus Coinfections in Febrile Patients in Sabah, Malaysia, 2019–2020. The American Journal of Tropical Medicine and Hygiene, tpmd250066. https://doi.org/10.4269/ajtmh.25-0066 Cite
Balingit, J. C., Abe, M., Suzuki, R., Xayavong, D., Ngwe Tun, M. M., Takamatsu, Y., Sonoda, K., & Morita, K. (2025). Cross-genotype immunogenicity and antibody-dependent enhancement of KD-382 dengue vaccine in flavivirus-naïve adults. Npj Vaccines, 10(1), 148. https://doi.org/10.1038/s41541-025-01204-y Cite
Ngwe Tun, M. M., John, J. L., Nabeshima, T., Manah, A. M., Takamatsu, Y., Urano, T., Morita, K., & Ahmed, K. (2025). Genomic analysis and molecular profiling of dengue viruses in Sabah, Malaysia during 2019-2020. IJID Regions, 16, 100712. https://doi.org/10.1016/j.ijregi.2025.100712 Cite
Shrestha, S., Rimal, S., Kharbuja, A., Ray, M. K., Shrestha, S., Dulal, A., Subedi, S., Khadka, A., Adhikari, N., Dhimal, M., Pandey, B. D., Urano, T., Morita, K., Ngwe Tun, M. M., & Dumre, S. P. (2025). Emergence of Dengue Virus Serotypes 1 and 3 in Mahottari and Adjacent Areas of Southern Nepal. Pathogens, 14(7), 639. https://doi.org/10.3390/pathogens14070639 Cite
Mutua, M. M., Rimal, S., Shrestha, S., Kharbuja, A., Dulal, A., Subedi, S., Bhandari Dumre, R., Khadka, A., Gautam, I., Luitel, H., Kapandji, M., Inoue, S., Takamatsu, Y., Pandey, B. D., Kaneko, S., Urano, T., Morita, K., Dumre, S. P., & Ngwe Tun, M. M. (2025). Detection of Dengue and Chikungunya Viruses in Mosquitoes from Nepal. The American Journal of Tropical Medicine and Hygiene, 113(2), 378–381. https://doi.org/10.4269/ajtmh.24-0685 Cite
Ngwe Tun, M. M., John, J. L., Nguyen, T. V., Mutua, M. M., Manah, A. M., Takamatsu, Y., Urano, T., Morita, K., & Ahmed, K. (2025). Prevalence of chikungunya virus infection in Sabah, Malaysia during 2017–2020. Tropical Medicine and Health, 53(1), 55. https://doi.org/10.1186/s41182-025-00735-3 Cite
Kang, H., Auzenbergs, M., Abbas, K., Maure, C., Moreno, L., Pascale, J. M., López-Vergès, S., Ortega-Barria, E., Kim, J., Luz, K., Warimwe, G., Tangkeangsirisin, W., Garrido, E. M. R., Robles, Y., De Cuellar, C. M., Vinhal, L., Gonzalez-Escobar, G., Ozturk, M., Dubischar, K., … Sahastrabuddhe, S. (2025). Stakeholder meeting report: Chikungunya virus – recent outbreaks, vaccine development and the way forward. Vaccine: X, 100730. https://doi.org/10.1016/j.jvacx.2025.100730 Cite
Jin, S., Asakura, T. R., Murayama, H., Niyukuri, D., Saila-Ngita, D., Lim, J. T., Endo, A., & Dickens, B. L. (2025). Vaccination strategies to achieve outbreak control for MPXV Clade I with a one-time mass campaign in sub-Saharan Africa: A scenario-based modelling study. PLOS Medicine, 22(9), e1004726. https://doi.org/10.1371/journal.pmed.1004726 Cite
Jin, S., Asakura, T. R., Murayama, H., Jung, S., Niyukuri, D., Nyandwi, J., Nkengurutse, L., Kamatari, O., Lim, J. T., Endo, A., & Dickens, B. L. (2025). Disentangling Temporal Trends of Clade Ib Monkeypox Virus Transmission in Burundi. The Journal of Infectious Diseases, jiaf475. https://doi.org/10.1093/infdis/jiaf475 Cite
Nakamura, T., Kinoshita, R., Endo, A., Atkins, K. E., Oshitani, H., Ibuka, Y., Suzuki, M., Ariyoshi, K., & O’Reilly, K. M. (2025). Continuing to be cautious: Japanese contact patterns during the COVID-19 pandemic and their association with public health recommendations. PLOS Global Public Health, 5(9), e0004600. https://doi.org/10.1371/journal.pgph.0004600 Cite
Too, E. K., Tun, T. Z., Chaiyawong, N., Ishizaki, T., Baba, M., Hakimi, H., Asada, M., Yahata, K., & Kaneko, O. (2025). A pseudokinase pPK4 is required for efficient red blood cell invasion and exflagellation center formation in Plasmodium yoelii. Parasitology International, 111, 103187. https://doi.org/10.1016/j.parint.2025.103187 Cite
Kang, H., Lim, A., Auzenbergs, M., Clark, A., Colón-González, F. J., Salje, H., Clapham, H., Carrera, J. P., Kim, J.-H., Malarski, M., López-Vergès, S., Cucunubá, Z. M., Cerqueira-Silva, T., Edmunds, W. J., Sahastrabuddhe, S., Brady, O. J., & Abbas, K. (2025). Global, regional and national burden of chikungunya: force of infection mapping and spatial modelling study. BMJ Global Health, 10(10), e018598. https://doi.org/10.1136/bmjgh-2024-018598 Cite
Han, S. M., Hon, P. S., Na, H. Y., Yong, T. T. H., Tambyah, P. A., & Wen, Y. T. (2025). Viral non-SARS-CoV-2 etiology of community-acquired pneumonia (CAP) in Southeast Asia: a review and pooled analysis. IJID Regions, 15, 100672. https://doi.org/10.1016/j.ijregi.2025.100672 Cite
Mutua, M. M., Ngwe Tun, M. M., Nwe, K. M., Lin, H., Kapandji, M., Inoue, S., Thant, K. Z., Takamatsu, Y., Aung, W. W., Khin, A. A., Thu, H. M., Urano, T., & Morita, K. (2025). Epidemiological insights into the co-circulation of Zika and dengue viruses in Yangon, Myanmar (2017-2019). Transactions of the Royal Society of Tropical Medicine and Hygiene, traf102. https://doi.org/10.1093/trstmh/traf102 Cite
Laraj, O., Benzina, B., Gzara, A., Kebir, A., Abbas, K., & BenMiled, S. (2025). Potential health impact and cost-effectiveness of human papillomavirus vaccination in Tunisia: A comparative modeling study. Vaccine: X, 27, 100712. https://doi.org/10.1016/j.jvacx.2025.100712 Cite
Kitamura, N., Tomo, Y., Okuyama, M., Ueda, K., Matsuoka, H., Morino, S., Miyahara, R., Yoneoka, D., Takanashi, S., & Suzuki, M. (2025). COVID-19 vaccine effectiveness and duration of protection among children and adolescents: A retrospective cohort study in 11 large cities in Japan. Vaccine, 63, 127656. https://doi.org/10.1016/j.vaccine.2025.127656 Cite
Ejima, K., Wang, Y., Endo, A., Murayama, H., Goh, Y. S., Cook, A. R., Jeong, Y. D., Iwami, S., Park, H., Dickens, B. S. L., Jin, S., Lim, J. T., Chan, C. E. Z., Chia, P. Y., Young, B. E., Yang, Y., Chio, M., Lye, D. C., & Ajelli, M. (2025). Evaluating the effectiveness of international travel controls to identify MPXV-infected travelers: a simulation study. BMC Medicine, 23(1), 473. https://doi.org/10.1186/s12916-025-04286-6 Cite
Jung, S., Miura, F., Murayama, H., Funk, S., Wallinga, J., Lessler, J., & Endo, A. (2025). Dynamic Landscape of Mpox Importation Risks Driven by Heavy-Tailed Sexual Contact Networks Among Men Who Have Sex With Men in 2022. The Journal of Infectious Diseases, 231(1), e234–e243. https://doi.org/10.1093/infdis/jiae433 Cite
Lee, N., Han, S. M., Mukadi, P., Edwards, T., Maung, H. T., Smith, C., & Win, T. Z. (2025). Corticosteroids for treatment of leptospirosis. Cochrane Database of Systematic Reviews, 2025(7). https://doi.org/10.1002/14651858.CD014935.pub2 Cite
Asakura, T. R., & O’Reilly, K. M. (2025). Assessing early detection ability through spatial arrangements in environmental surveillance for poliovirus: A simulation-based study. PLOS One, 20(7), e0325789. https://doi.org/10.1371/journal.pone.0325789 Cite
Asakura, T., Jung, S., Murayama, H., Ghaznavi, C., Sakamoto, H., Teshima, A., Miura, F., & Endo, A. (2025). Modelling international spread of clade IIb mpox on the Asia continent. Bulletin of the World Health Organization, 103(7), 429–436. https://doi.org/10.2471/BLT.24.291815 Cite
Jung, S., Miura, F., Murayama, H., Funk, S., Wallinga, J., Lessler, J., & Endo, A. (2025). Preemptive Mpox Vaccine Deployment: Aligning Strategy With Reality. The Journal of Infectious Diseases, jiaf365. https://doi.org/10.1093/infdis/jiaf365 Cite
Kim, C., Frost, I., Naylor, N. R., Au, H., Kim, Y., Lee, Y., Bzymek, A., Majgier, K., Moldoveanu, A. L., Salman, O. M., Simiyu, S., Youssef, D. M., Hasso-Agopsowicz, M., & Abbas, K. (2025). Length of hospital stay and associated treatment costs for patients with susceptible and antibiotic-resistant Salmonella infections: a systematic review and meta-analysis. BMJ Open, 15(6), e092494. https://doi.org/10.1136/bmjopen-2024-092494 Cite
Naylor, N. R., Hasso-Agopsowicz, M., Kim, C., Ma, Y., Frost, I., Abbas, K., Aguilar, G., Fuller, N., Robotham, J. V., & Jit, M. (2025). The global economic burden of antibiotic-resistant infections and the potential impact of bacterial vaccines: a modelling study. BMJ Global Health, 10(6). https://doi.org/10.1136/bmjgh-2024-016249 Cite
Wang, C., Lai, X., Abbas, K., Pouwels, K. B., Zhang, H., Jit, M., & Fang, H. (2025). Health impact and economic evaluation of the Expanded Program on Immunization in China from 1974 to 2024: a modelling study. The Lancet Public Health, S2468266725000398. https://doi.org/10.1016/S2468-2667(25)00039-8 Cite
Ngwe Tun, M. M., Mutua, M. M., Inoue, S., Takamatsu, Y., Kaneko, S., Urano, T., Muthugala, R., Fernando, L., Hapugoda, M., Gunawardene, Y., & Morita, K. (2025). Molecular and serological evidence of chikungunya virus among dengue suspected patients in Sri Lanka. Journal of Infection and Public Health, 18(5), 102709. https://doi.org/10.1016/j.jiph.2025.102709 Cite
Bharati, N., Dumre, S. P., Shah, Y., Nabesima, T., Dhimal, M., Pandey, S., Kapandji, M., Takamatsu, Y., Urano, T., Pandey, B. D., Morita, K., Ngwe Tun, M. M., & Pandey, K. (2024). Circulating serotypes and genotypes of dengue virus during the 2023 outbreak in Eastern Nepal. Journal of Clinical Virology, 174, 105721. https://doi.org/10.1016/j.jcv.2024.105721 Cite
Balingit, J. C., Denis, D., Suzuki, R., Hayati, R. F., Ngwe Tun, M. M., Takamatsu, Y., Masyeni, S., Sasmono, R. T., & Morita, K. (2024). Impact of pre-existing cross-reactive antibodies on cyclic dengue outbreaks in the hyperendemic region of Bali, Indonesia. Virus Research, 348, 199445. https://doi.org/10.1016/j.virusres.2024.199445 Cite
Furuse, Y. (2022). Cartography of SARS‐CoV‐2 variants based on the susceptibility to therapeutic monoclonal antibodies. Journal of Medical Virology, 95(1), e28275. https://doi.org/10.1002/jmv.28275 Cite
Kim, S., Kang, H., Skrip, L., Sahastrabuddhe, S., Islam, A., Jung, S.-M., Vesga, J. F., Endo, A., Edmunds, W. J., & Abbas, K. (2025). Progress and challenges in Nipah vaccine development and licensure for epidemic preparedness and response. Expert Review of Vaccines, 24(1), 183–193. https://doi.org/10.1080/14760584.2025.2476523 Cite
A, J., Gan, G., Endo, A., Jin Tan, R. K., Prem, K., & Dickens, B. L. (2025). Is Southeast Asia and the Western Pacific ready for potential monkeypox virus outbreaks? The Lancet Regional Health - Western Pacific, 57, 101526. https://doi.org/10.1016/j.lanwpc.2025.101526 Cite
Han, S. M., Shiino, T., Masuda, S., Furuse, Y., Yasaka, T., Kanda, S., Komori, K., Saito, N., Kubo, Y., Smith, C., Endo, A., Robert, A., Baguelin, M., & Ariyoshi, K. (2025). Phylogenetic Study of Local Patterns Influenza A(H3N2) Virus Transmission in a Semi‐Isolated Population in a Remote Island in Japan Between 2011 and 2013. Influenza and Other Respiratory Viruses, 19(3), e70089. https://doi.org/10.1111/irv.70089 Cite
Auzenbergs, M., Abbas, K., Peak, C. M., Voorman, A., Jit, M., & O’Reilly, K. M. (2025). Vaccination strategies against wild poliomyelitis in polio-free settings: outbreak risk modelling study and cost-effectiveness analysis. BMJ Global Health, 10(3), e016013. https://doi.org/10.1136/bmjgh-2024-016013 Cite
Maure, C., Khazhidinov, K., Kang, H., Auzenbergs, M., Moyersoen, P., Abbas, K., Santos, G. M. L., Medina, L. M. H., Wartel, T. A., Kim, J. H., Clemens, J., & Sahastrabuddhe, S. (2024). Chikungunya vaccine development, challenges, and pathway toward public health impact. Vaccine, 42(26), 126483. https://doi.org/10.1016/j.vaccine.2024.126483 Cite
Hoa-Tran, T. N., Nakagomi, T., Vu, H. M., Nguyen, T. T. T., Dao, A. T. H., Nguyen, A. T., Bines, J. E., Thomas, S., Grabovac, V., Kataoka-Nakamura, C., Taichiro, T., Hasebe, F., Kodama, T., Kaneko, M., Dang, H. T. T., Duong, H. T., Anh, D. D., & Nakagomi, O. (2024). Evolution of DS-1-like G8P[8] rotavirus A strains from Vietnamese children with acute gastroenteritis (2014–21): Adaptation and loss of animal rotavirus-derived genes during human-to-human spread. Virus Evolution, 10(1), veae045. https://doi.org/10.1093/ve/veae045 Cite
Ngwe Tun, M. M., Luvai, E. A. C., Toizumi, M., Moriuchi, M., Takamatsu, Y., Inoue, S., Urano, T., Bui, M. X., Thai Hung, D., Thi Nguyen, H.-A., Anh, D. D., Yoshida, L.-M., Moriuchi, H., & Morita, K. (2024). Possible vertical transmission of Chikungunya virus infection detected in the cord blood samples from a birth cohort in Vietnam. Journal of Infection and Public Health, 17(6), 1050–1056. https://doi.org/10.1016/j.jiph.2024.04.012 Cite
Paul, K. M. M., Simpson, S. V., Nundu, S. S., Arima, H., & Yamamoto, T. (2024). Genetic diversity of glutamate-rich protein (GLURP) in Plasmodium falciparum isolates from school-age children in Kinshasa, DRC. Parasitology International, 100, 102866. https://doi.org/10.1016/j.parint.2024.102866 Cite
Balingit, J. C., Dimamay, M. P. S., Suzuki, R., Matsuda, M., Xayavong, D., Ngwe Tun, M. M., Matias, R. R., Natividad, F. F., Moi, M. L., Takamatsu, Y., Culleton, R., Buerano, C. C., & Morita, K. (2023). Role of pre-existing immunity in driving the dengue virus serotype 2 genotype shift in the Philippines: A retrospective analysis of serological data. International Journal of Infectious Diseases, 139, 59–68. https://doi.org/10.1016/j.ijid.2023.11.025 Cite
Mogasale, V. V., Sinha, A., John, J., Hasan Farooqui, H., Ray, A., Chantler, T., Mogasale, V., Gopal Dhoubhadel, B., John Edmunds, W., Clark, A., & Abbas, K. (2024). Typhoid conjugate vaccine implementation in India: A review of supportive evidence. Vaccine: X, 21, 100568. https://doi.org/10.1016/j.jvacx.2024.100568 Cite
Shrestha, S., Bajracharya, M., Rimal, S., Bhujel, R., Chalise, B., Basaula, Y. N., Amatya, P., Pandey, S., Joshi, P., Adhikari, N., Ngwe Tun, M. M., Morita, K., Dumre, S. P., & Pandey, B. D. (2024). A challenge to clinical management: A case of expanded dengue syndrome co-infection with dengue 1 and dengue 3 serotypes in Nepal. Medical Reports, 8, 100123. https://doi.org/10.1016/j.hmedic.2024.100123 Cite
Mogasale, V. V., Sinha, A., John, J., Hasan Farooqui, H., Ray, A., Chantler, T., Mogasale, V., Dhoubhadel, B. G., Edmunds, W. J., Clark, A., & Abbas, K. (2024). Research priorities to support typhoid conjugate vaccine decision-making in India: evidence assessment and stakeholder survey. BMJ Public Health, 2(2), e001089. https://doi.org/10.1136/bmjph-2024-001089 Cite
Hartner, A.-M., Li, X., Echeverria-Londono, S., Roth, J., Abbas, K., Auzenbergs, M., De Villiers, M. J., Ferrari, M. J., Fraser, K., Fu, H., Hallett, T., Hinsley, W., Jit, M., Karachaliou, A., Moore, S. M., Nayagam, S., Papadopoulos, T., Perkins, T. A., Portnoy, A., … Gaythorpe, K. A. M. (2024). Estimating the health effects of COVID-19-related immunisation disruptions in 112 countries during 2020–30: a modelling study. The Lancet Global Health, 12(4), e563–e571. https://doi.org/10.1016/S2214-109X(23)00603-4 Cite
Abbas, K., Yoo, K. J., Prem, K., & Jit, M. (2024). Equity impact of HPV vaccination on lifetime projections of cervical cancer burden among cohorts in 84 countries by global, regional, and income levels, 2010–22: a modelling study. eClinicalMedicine, 102524. https://doi.org/10.1016/j.eclinm.2024.102524 Cite
Kang, H., Auzenbergs, M., Clapham, H., Maure, C., Kim, J.-H., Salje, H., Taylor, C. G., Lim, A., Clark, A., Edmunds, W. J., Sahastrabuddhe, S., Brady, O. J., & Abbas, K. (2024). Chikungunya seroprevalence, force of infection, and prevalence of chronic disability after infection in endemic and epidemic settings: a systematic review, meta-analysis, and modelling study. The Lancet Infectious Diseases, S1473309923008101. https://doi.org/10.1016/S1473-3099(23)00810-1 Cite
Murayama, H., Endo, A., & Yonekura, S. (2023). Estimation of waning vaccine effectiveness from population-level surveillance data in multi-variant epidemics. Epidemics, 45, 100726. https://doi.org/10.1016/j.epidem.2023.100726 Cite
Flandes, X., Hansen, C. A., Palani, S., Abbas, K., Bennett, C., Caro, W. P., Hutubessy, R., Khazhidinov, K., Lambach, P., Maure, C., Marshall, C., Rojas, D. P., Rosewell, A., Sahastrabuddhe, S., Tufet, M., Wilder-Smith, A., Beasley, D. W. C., Bourne, N., & Barrett, A. D. T. (2024). Vaccine value profile for Chikungunya. Vaccine. https://doi.org/10.1016/j.vaccine.2023.07.069 Cite
Fu, H., Abbas, K., Malvolti, S., Gregory, C., Ko, M., Amorij, J.-P., & Jit, M. (2023). Impact and cost-effectiveness of measles vaccination through microarray patches in 70 low-income and middle-income countries: mathematical modelling and early-stage economic evaluation. BMJ Global Health, 8(11), e012204. https://doi.org/10.1136/bmjgh-2023-012204 Cite
Nwe, K. M., Tun, M. M. N., Muthugala, R., Nabeshima, T., Balingit, J. C., Rajamanthri, L., Jayawardana, D., Attanayake, S., Inoue, S., Takamatsu, Y., Urano, T., & Morita, K. (2023). Clinical, Virological, and Immunological Features in Cosmopolitan Genotype DENV-2–Infected Patients during a Large Dengue Outbreak in Sri Lanka in 2017. The American Journal of Tropical Medicine and Hygiene, 109(4), 917–925. https://doi.org/10.4269/ajtmh.22-0780 Cite
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