• 我が国のワクチン発祥の地、
    長崎から新たに始まるワクチン開発研究
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ワクチン研究開発拠点について

長崎大学感染症研究出島特区 ワクチン研究開発拠点は,「ワクチン開発のための世界トップレベル研究開発拠点の形成事業」に採択された4つのシナジー拠点の一つです。長崎大学がこれまで研究してきた高病原性病原体や熱帯性病原体を対象としたワクチン開発を推進し,人類の脅威となる感染症に対するワクチン開発を目指します。
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12924226 1 apa 5 default desc year 1 54 https://dida.nagasaki-u.ac.jp/dida_wp/wp-content/plugins/zotpress/
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Too, E. K., Tun, T. Z., Chaiyawong, N., Ishizaki, T., Baba, M., Hakimi, H., Asada, M., Yahata, K., & Kaneko, O. (2025). A pseudokinase pPK4 is required for efficient red blood cell invasion and exflagellation center formation in Plasmodium yoelii. Parasitology International, 111, 103187. https://doi.org/10.1016/j.parint.2025.103187
Kang, H., Lim, A., Auzenbergs, M., Clark, A., Colón-González, F. J., Salje, H., Clapham, H., Carrera, J. P., Kim, J.-H., Malarski, M., López-Vergès, S., Cucunubá, Z. M., Cerqueira-Silva, T., Edmunds, W. J., Sahastrabuddhe, S., Brady, O. J., & Abbas, K. (2025). Global, regional and national burden of chikungunya: force of infection mapping and spatial modelling study. BMJ Global Health, 10(10), e018598. https://doi.org/10.1136/bmjgh-2024-018598
Han, S. M., Hon, P. S., Na, H. Y., Yong, T. T. H., Tambyah, P. A., & Wen, Y. T. (2025). Viral non-SARS-CoV-2 etiology of community-acquired pneumonia (CAP) in Southeast Asia: a review and pooled analysis. IJID Regions, 15, 100672. https://doi.org/10.1016/j.ijregi.2025.100672
Mutua, M. M., Ngwe Tun, M. M., Nwe, K. M., Lin, H., Kapandji, M., Inoue, S., Thant, K. Z., Takamatsu, Y., Aung, W. W., Khin, A. A., Thu, H. M., Urano, T., & Morita, K. (2025). Epidemiological insights into the co-circulation of Zika and dengue viruses in Yangon, Myanmar (2017-2019). Transactions of the Royal Society of Tropical Medicine and Hygiene, traf102. https://doi.org/10.1093/trstmh/traf102
Laraj, O., Benzina, B., Gzara, A., Kebir, A., Abbas, K., & BenMiled, S. (2025). Potential health impact and cost-effectiveness of human papillomavirus vaccination in Tunisia: A comparative modeling study. Vaccine: X, 27, 100712. https://doi.org/10.1016/j.jvacx.2025.100712
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